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The Research and Development team at Foundation Medicine is constantly pushing the envelope to transform cancer care.

Watch the video to see how each member has the chance to make a real impact. 


Principal Scientist Computational Biology

  • Boston, Massachusetts, United States
  • Full Time

Key Responsibilities

• Integrate clinical DNA-seq and RNA-seq diagnostic assays into a unified platform that supports FMI’s product portfolio expansion, in close collaboration with a multidisciplinary team of scientists, engineers and computational biologists.

• Provide advanced scientific support to strategic external relationships with technology providers, pharmaceutical companies and academic partners, in collaboration with Business Development, Clinical and Commercial Teams.

• Lead the development and deployment of high throughput automation, NGS-based systems and workflows, as well as new and emerging genomic and transcriptomic methodologies.

• Lead a group of Scientists in the achievement of organizational goals.

• Guide, coach, direct, develop, and hire direct reports, if applicable.

• Periodically other projects and duties pertinent to that of a Principal Scientist.



Basic Qualifications

• PhD in a life science discipline

• 5+ years working in industry and/or academia

• Proficiency with Python and/or Java programming languages


Preferred Qualifications

• PhD in Molecular Biology, Biochemistry, or Genetics

• Extensive experience in:

·   Standard molecular biology techniques and

·   The development and/or implementation of genomic assays in a regulated environment (CLIA, CAP, GxP, ISO, etc.) including writing standard operating procedures, validation protocols and data reports

• Solid knowledge of molecular biology, high throughput automation and next generation sequencing

• Understanding of the practices and principals of NGS, including DNA-seq and RNA-seq protocols, and various target-enrichment approaches (e.g. multiplex-PCR, hybrid selection)

• Familiarity with robotic liquid handlers, lab automation and instrumentation

• Expertise in scientific processes and assay parameters, with history of creative problem-solving approach to inform assay troubleshooting and optimization

• Extensive research and clinical lab experience in a dynamic, multidisciplinary environment

• Demonstrated ability to clearly communicate scientific results in internal and external presentations and publications

• Results oriented, track record of achieving individual and organizational objectives

• Demonstrated ability to work independently and collaboratively in a dynamic, fast paced team environment

• Understanding of HIPAA and the importance of patient data privacy

• Commitment to reflect FMI’s values: passion, patients, innovation and collaboration

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