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Sr Research Associate

  • Cambridge, Massachusetts, United States
  • Full Time

About the Job

The Senior Research Associate (SRA), Product Development leads and manages the participation in internal research projects and development of Next Generation Sequencing (NGS)-based molecular diagnostic assays for this purpose. As a senior-level position, the incumbent is responsible for leveraging additional years of experience and/or education for a more advanced level of analysis and research activities. The SRA prepares and analyzes human specimens, conducts laboratory experiments within guidelines and operates and maintains complex scientific equipment, such as high throughput liquid handlers. Additionally, SRA evaluates and summarizes results, prepares reports, presents data, and remains up-to-date with current publications relative to methods and techniques within relevant areas of research to leverage and integrate these. 

The SRA will work within the Assay Development group to help drive updates to Foundation Medicine’s liquid biopsy comprehensive genomic profiling (CGP) assay. The main responsibilities of the SRA will be to contribute to the planning, execution and analysis of the laboratory experiments for the assessment and development of assay improvements. This role will have the unique opportunity to work cross-functionally in a product development environment to advance Foundation Medicine’s market-leading CGP tests focused at improving outcomes for cancer patients.

 

Key Responsibilities

• Prepare and isolates nucleic acid from oncology specimens (such as DNA/RNA extraction from FFPE tissues).

• Perform standard molecular biology techniques (such as enzymatic manipulation of DNA and RNA).

• Perform specialized and complex experiments in such areas of Next generation sequencing.

• Operate complex laboratory equipment such as laboratory automation equipment.

• Perform calculations and statistical analysis of research test results.

• Maintain detailed notes of the experimental data in notebook or computer database.

• Prepare reports and presentations to communicate results in group meetings.

• Train and mentor research assistants and/or research associates on optimal processes and standard operating procedures.

• Participate in training sessions and workshops.

• Perform lab testing independently.

• Other duties as assigned.

 

Qualifications

Basic Qualifications

• Bachelor’s Degree in Molecular Biology or a related life science fields

• 3+ years of life science research experience in industry, a clinical research organization, or a hospital

 

Preferred Qualifications

• Master’s Degree in Molecular Biology or a related life science field

• Experience working with typical oncology specimens including Formalin-fixed, Paraffin-embedded (FFPE) tissue samples, blood, bone marrow

• Experience working with standard molecular biology techniques (nucleic acid isolation and analysis, Polymerase Chain Reaction (PCR), and enzymatic manipulation of DNA and RNA

• Demonstrate a good understanding of the practices and principals of NGS, including DNA-seq and RNA-seq protocols, and various target-enrichment approaches e.g. multiplex-PCR, hybrid selection

• Familiarity with liquid handling equipment such as Hamilton Star or Agilent Bravo

• Proficiency in the following software:

·   Microsoft Office suite, particularly Word and Excel

·   JMP statistical software

• Demonstrated ability to effectively communicate, both written and verbal, scientific concepts, experimental plans, and result

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