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Principal Scientist, Computational Biology

  • 400 Summer Street, Boston, Massachusetts, United States
  • Full Time

About the Job

The Principal Scientist, Computational Biology leads the development and deployment of computational methods for NGS-based clinical diagnostic assays in our clinical labs. Working as part of a large multidisciplinary team, this role distills the latest advances in computational methods, genomics, and oncology to develop innovative, best-in-class clinical diagnostic tools. The successful candidate will have a deep understanding of genomics, cancer biology, and computational biology, and will have a track record of working on cross-functional teams to deliver on complex projects.

Key Responsibilities

  • Develop computational methodology and perform critical analyses to support development of new products and improvements to existing products, both as an individual contributor and/or as a team leader.
  • Collaborate with cross-functional teams including members from assay development, software engineering, marketing, quality, regulatory, and others to execute complex product development projects.
  • Work closely with bench scientists to develop and optimize new wet-lab protocols in concert with computational biology development efforts.
  • Analyze large genomic and epigenomic datasets using cutting-edge computational biology methods to identify genomic alterations and biomarkers associated with cancer onset and progression and to craft novel tools to detect those patterns.
  • Communicate scientific findings and project progress to project teams and senior leadership.
  • Guide, coach, direct, develop, and hire direct reports, if applicable.
  • Other duties as assigned.


Basic Qualifications:

  • PhD in a life science or computational discipline.
  • 5+ years of postdoctoral research or professional experience related to NGS or cancer diagnostics.

Preferred Qualifications:

  • Proficiency with Python or a closely related programming language.
  • Life sciences industry experience in genomics, molecular insights, and/or diagnostics including regulated diagnostics development
  • Experience with cancer biology, cell biology, genetics, epigenetics or molecular biology, esp. working with large biological data sets to address focused biological questions in oncology
  • Experience developing algorithms and tools for analysis of large data sets, including prior experience with genomic and NGS data
  • Advanced software development skills (including substantial experience with Python, Java, R, and/or C++) as well as experience with computational technologies such as databases (SQL) and cloud computing (esp. AWS)
  • Sound knowledge of current bioinformatics trends, available genomic and epigenetic bioinformatic tools and databases
  • Ability to adapt to changing procedures, policies, and work environment
  • Excellent organization skills with a demonstrated attention to detail
  • Excellent written and verbal communication skills
  • Understanding of HIPAA and importance of privacy of patient data
  • Commitment to reflect FMI’s values: Passion, Patients, Innovation, and Collaboration


About Foundation Medicine

Foundation Medicine began with an idea—to simplify the complex nature of cancer genomics, bringing cutting-edge science and technology to everyday cancer care. Our approach generates insights that help doctors match patients to more treatment options and helps accelerate the development of new therapies. Foundation Medicine is the culmination of talented people coming together to realize an important vision, and the work we do every day impacts real lives.

Confidence, or the belief that we need to check every box before applying for a job, can sometimes hold us back from going after a role that inspires us. At Foundation Medicine there's no such thing as the 'perfect' applicant, and our company is a place where every employee can make an impact and continue to grow whatever background they may have or path they may have taken. So, as long as you meet the basic qualifications for a role, please apply if you see a position that would make you excited to come into Foundation Medicine every day and help us transform cancer care.

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Foundation Medicine is proud to be an Equal Opportunity and Affirmative Action employer and considers all qualified applicants for employment without regard to race, color, religion, sex, gender, sexual orientation, gender identity, ancestry, age, or national origin. Further, qualified applicants will not be discriminated against on the basis of disability or protected veteran status. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements. See also FMI’s EEO Statement and EEO is the Law and Supplement. If you have a disability or special need that requires accommodation, please let us know by completing this form.  (EOE/AAP Employer)

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