About the Job

The Senior Research Associate (SRA), Assay Development supports feasibility, development, design, and laboratory systems integration of Next Generation Sequencing (NGS)-based molecular diagnostic assays for internal and external research projects. As a Senior Research Associate position, the incumbent is responsible for leveraging additional years of experience and/or education for a more advanced level of analysis and research activities. The SRA prepares and analyzes human specimens, conducts laboratory experiments within guidelines, and operates and maintains complex scientific equipment, such as high throughput liquid handlers. Additionally, the SRA evaluates and summarizes results, prepares reports, presents data, and remains up to date with current publications relative to methods and techniques within relevant areas of research to leverage and integrate these into products developed by Foundation Medicine. This role will have the unique opportunity to work cross-functionally in a product development environment to advance Foundation Medicine's existing and new products focused at improving outcomes for cancer patients.

Key Responsibilities

• Prepare and isolate nucleic acid from oncology specimens (such as DNA/RNA extraction from FFPE tissues and plasma samples).
• Perform standard molecular biology techniques (such as enzymatic manipulation of DNA and RNA).
• Perform specialized and complex experiments in such areas of Next Generation Sequencing.
• Operate complex laboratory equipment such as high throughput liquid handlers and Illumina sequencers.
• Support the timely processing and reporting of oncology samples to internal and external collaborators.
• Manage experimental data in a computer database (e.g. LIMS).
• Analyze and troubleshoot research test results.
• Maintain detailed notes of experimental data with proper documentation.
• Prepare reports and presentations to communicate results in group meetings.
• Develop and follow SOPs.
• Train and mentor other team members on standard operating procedures.
• Participate in training sessions and workshops.
• Independently perform lab testing.
• Other duties as assigned.

Qualifications:

Basic Qualifications:

• Bachelor's Degree in Molecular Biology or a related life science field and 4+ year of life science research experience in industry, a clinical research organization, or a hospital; OR
• Master's Degree in Molecular Biology or a related life science field

Preferred Qualifications:

• Master's Degree in Molecular Biology or a related life science field
• Experience working with typical oncology specimens including Formalin-fixed, Paraffin-embedded (FFPE) tissue samples and plasma from whole blood
• Experience working with standard molecular biology techniques (nucleic acid isolation and analysis, Polymerase Chain Reaction (PCR), qPCR, and enzymatic manipulation of DNA and RNA)
• Experience with high throughput automation and liquid handling equipment (such as Hamilton Star, KingFisher)
• Demonstrate good understanding of the practices and principals of NGS, including DNA-seq and RNA-seq protocols, and various target-enrichment approaches e.g. multiplex-PCR, hybrid selection
• Demonstrate ability to effectively communicate, both written and verbal, scientific concepts, experimental plans, and results
• Proficiency in Microsoft Office suite, particularly Word, Power Point, Excel
• Proficiency in data visualization and statistical software (such as JMP)
• Understanding of HIPAA and importance of privacy of patient data
• Commitment to reflect FMI's values: Integrity, Courage, and Passion

The expected salary range for this position based on the primary location of Boston, MA is $86,400 - $103,000 per year. The salary range is commensurate with Foundation Medicines compensation practice and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for Foundation Medicine's benefits.

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